CAS 1260141-27-2|TAK-438

CAS: 1260141-27-2 is chemically named Vonoprazan fumarate, also known as TAK-438. Its molecular formula is C21H20FN3O6S, and its molecular weight is 461.4634032. Its EINECS number is 250-635-4.

Vonoprazan fumarate is a white to off-white solid that is insoluble in water and ethanol, but has a solubility of Greater than or equal to 18.9 mg/mL in DMSO. Its storage condition is -20 degree .

Vonoprazan fumarate is used to treat erosive esophagitis, gastric ulcers, and duodenal ulcers ‌‌12. This compound is a potassium ion (K+) competitive acid blocker (P-CAB), which is a reversible proton pump inhibitor. It inhibits the binding of K+ to H+-K+-ATPase (proton pump) to terminate gastric acid secretion, thereby achieving an acid-suppressing effect. It has a strong and lasting inhibitory effect on gastric acid secretion‌.

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